The conditions of the 6 AM crash remain unclear, reports NBC News. Weather conditions were normal and no one knows if there were any mechanical failures with the plane itself.
The cargo plane, identified as Flight 1354, crashed into a field owned by Birmingham-Shuttlesworth International Airport, exploding twice and strewing debris in its path. It is not known if there have been any injuries or deaths related to the crash.
All roads to the airport are currently shut down, reports ABC News.
UPDATE: Fox News confirms that both pilots were killed. The nose of the plane (AP photo of the crash is above) separated in the crash, which was outside the fence of the Birmingham airport.